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Subclinical Hypothyroidism: How Many Cases Are We Missing?

The Problem with Reference Ranges Patients frequently present with fatigue, hair loss, cold intolerance, weight gain, morning somnolence, or diffuse muscle pain. Yet, their thyroid laboratory values often remain “within normal limits.” This discrepancy arises from the fact that laboratory reference ranges are statistical, not physiological. They reflect the distribution of values within a population […]

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